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Albumin as curcumin delivery vehicle for anti-cancer activity
By Sree Chitra Tirunal Institute for Medical Sciences & Technology(SCTIMST)
Most of the anti-cancer drugs damage many cell types; therefore, intense research discovered new molecules but with various limitations. Curcumin is a natural molecule that proves potential anti-cancer properties for human use. But its poor aqueous solubility and bioavailability limits its effective use. The technology tries to address this limitation.
Product Design and Silent Features
Chemical-free conjugation to native albumin with high binding efficiency achieves high concentration of biologically active curcumin in aqueous medium. Curcumin solubility in conjugated form is 100 fold higher than free curcumin. Action of Curc-Alb on cancer cells has been established in vitro and in vivo. Human albumin in its native form and pH is used for conjugation of Curcumin. Albumin infusion to cancer patients is a standard therapeutic method. So transfusion of Curc-Alb conjugate may not cause hazard to the patient as compared to many caustic drugs given for treatment. Patent: PCT/IN2014/000338
Development Stage
Pharamacokinetics/ Pharmacodynamics (PK/PD) study in progress. Industry can collaborate for further development and commercialization
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