Skin Substitute : PLGC-F-HA
By Sree Chitra Tirunal Institute for Medical Sciences & Technology(SCTIMST)
Deep wounds in diabetic and burn subjects often become a health problem leading to morbidity and mortality. Currently, autologous skin grafting is the Golden Standard to treat such wounds; many of the wound care products available in the market are not suitable for skin substitution. The available products are costly.
Product Design and Silent Features
The product is a combination matrix formed from human plasma derived, pharmacopoeia grade Fibrin Sealant (F), hyaluronic acid (HA) and synthetic degradable monomers which are approved by USFDA for clinical use. The PLGC synthesized and characterized is provided as a nanofibrous electrospun mat with fibers ranging from 5 to 80 nm in diameter embedded in polymerized human F and HA.PLGC-F-HA was developed to match the physicochemical properties of native skin in terms of tensile strength, water permeability and elasticity. Safety of PLGC was proven using selected toxicological tests from ISO10993.
Development Stage
Industry shall collaborate and take forward the evaluations and commercialization.
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